Polyglycolic acid; CAS Number: 26009-03-0; Synonym: PGA, Poly(2-hydroxyacetic acid); find Sigma-Aldrich-46746 MSDS, related peer-reviewed papers, technical documents, similar products & … The effect of 60Co γ radiation on the molecular properties of PGA is also shown. ), thermogravimetric analysis (t.g.a.) Polyglycolic acid (PGA) and poly lactic- co -glycolic acid (PLGA) sutures were introduced in the 1970s as the first synthetic absorbable synthetic sutures and are still used today. Polyglycolic Acid is used to produce absorbable, synthetic and braided multifilament sutures. While known since 1954, PGA had found little use because of its sensitivity to hydrolysis when compared with other synthetic polymers. In this study; to improve on the physical properties of PGA, such as melting temperature and solubility, polymerizations of trioxane, CO and a minor amount of epoxides with long side chains were performed under the same reaction condition as PGA homopolymer synthesis (DCM solvent, at 800 psi, with triflic acid catalyst, reaction time of 72 h). biomedical applications due to insolubility of PGA in most of the solvents and rapid degradation of PGA. In this article we will focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired. The solubilities of obtained copolymers also increased by increasing side chain length of epoxides in the polymer backbone. Scientists and researchers keep on improving this material via their studies and research, in order to come up with sustainable properties with the finest products. To improve on the physical properties of PGA, such as solubility and appearance, copolymerization of trioxane, CO, and a minor amount of epoxides derived from polyethylene glycol (PEG) were performed under the same reaction conditions for PGA synthesis (in DCM, at 800 psi CO pressure, with triflic acid catalyst, reaction duration of 72 hours). The resulting samples were characterized by gel permeation chromatography (g.p.c. Poly(glycolic acid) (PGA) has a similar chemical structure to PLA but without the methyl side group, which allows the polymer chains to pack together tightly and results in a high degree of crystallinity (45–55%), high thermal stability (Tm = 220–230 °C), exceptionally high gas barrier (3 times higher than EVOH), as well as high mechanical strength (115 MPa) and stiffness (7 GPa). XX is the XXth reference in the list of references. A series of biodegradable poly(ether−anhydrides) composed of poly(ethylene glycol) (PEG), sebacic acid (SA), and 1,3-bis(carboxyphenoxy)propane (CPP) were synthesized for use in advanced drug delivery applications. Regarding polymeric NPs, these are commonly employed in the biomedical field due to their characteristics of compatibility, biodegradability and low cytotoxicity [24], where natural polymers like chitosan, modified starches and natural gums are very usual [33]. Our previous studies revealed an alternative method for the synthesis of PGA from the perfectly alternating copolymerization of formaldehyde (from trioxane) and carbon monoxide (CO) under BrØnsted acidic conditions. Corresponding authors, a The respective reactivity ratios of glycolide and lactide are elucidated. Poly(lactic acid-co-lysine) was synthesized and utilized for attaching a peptide containing the arginine–glycine–aspartic acid (RGD) sequence to enhance cell adhesion. 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